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Cyclic GMP-dependent protein kinase type I (cGKI) exerts a cytoprotective function, as cGKI-deficient mice exhibit anemia and splenomegaly due to accelerated erythrocyte clearanceunderscoring cGKIs capacity to buffer pro-eryptotic signals ( 2+ activity, and its activator pyrvinium pamoate further influences this process via activating Cl -sensitive Ca 2+ -permeable cation channels and inhibiting Ca 2+ -activated K + channels (Kucherenko et al., 2012

Once it enters the cytoplasm, glutamine is hydrolyzed to glutamate and ammonia (NH 3 ) via GLS (Fig

Conflicts of interest There are no conflicts of interest

The Ct-derived expression values were adjusted by a common scaling factor to ensure that the average of control values equaled 1 or 100